DNAJA4

Across TCGA pan-cancer cohorts, DNAJA4 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DNAJA4 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DNAJA4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAJA4 expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCEC show a favorable association.

UVM, KIRP, and SKCM are the cancer types where DNAJA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.222	0.656	.001	74	view →
KIRP	DFS	Quartile	All	0.953	0.751	<.001	49	view →
SKCM	OS	Quartile	All	0.259	0.440	.005	46	view →
LGG	DFS	Median	All	0.671	0.798	<.001	42	view →
UCEC	OS	Quartile	III,IV	0.932	0.738	.005	32	view →
KIRC	DFS	Quartile	All	0.801	0.430	<.001	32	view →
COAD	OS	Tertile	IV	0.248	0.860	.003	27	view →
GBM	DFS	Tertile	All	0.152	0.328	.003	27	view →
ESCA	DFS	Tertile	II,III,IV	0.408	0.618	.012	25	view →
PAAD	OS	Tertile	All	0.387	0.692	.006	17	view →
ACC	OS	Tertile	IV	0.708	0.320	.019	9	view →
CESC	DFS	Quartile	III,IV	0.616	0.890	.026	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DNAJA4–UVM (DFS)

Open the UVM breakdown →