DNAJA4

Across TCGA pan-cancer cohorts, DNAJA4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DNAJA4 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DNAJA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNAJA4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, LUSC, and SKCM are the cancer types where DNAJA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.199	0.903	<.001	15	view →
LUSC	OS	Median	All	0.180	0.676	.002	15	view →
SKCM	DFS	Median	All	0.055	0.731	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.079	0.429	.003	6	view →
UCEC	DFS	Median	All	0.950	0.621	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DNAJA4–KIRP (OS)

Open the KIRP breakdown →