DNAJA1

Across TCGA cell cohorts, DNAJA1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DNAJA1-associated genes across cancer lineages are ACSM6, GJA10, and RIT2. Each is linked with DNAJA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJA1-to-partner and partner-to-DNAJA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by DNAJA1-low versus DNAJA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJA1→partner) and Y-score (partner→DNAJA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1
LUNG_NSCLC_LUAD	GJA10 →	+0.045	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	RIT2 →	+1.030	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	PNLIP →	+0.003	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	SPATA31D4 →	+0.003	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	FABP12 →	+0.129	+3.215	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ACSM6 by DNAJA1 expression — LARGE_INTESTINE

Explore this box plot interactively →