DNAI3

Across TCGA patient cohorts, DNAI3 mutation is significantly associated with the RNA expression of many other genes, with 4,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAI3-associated genes across cancer lineages are ANKRD33B-AS1, RAD17, and CWC27. Each is linked with DNAI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAI3-to-partner and partner-to-DNAI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD33B-AS1 grouped by DNAI3-low versus DNAI3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI3→partner) and Y-score (partner→DNAI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	ANKRD33B-AS1 →	+0.187	+6.681	<.001	<.001	3	2
UCEC	RAD17 →	+0.414	+1.830	<.001	<.001	3	2
UCEC	CWC27 →	+0.489	+2.280	<.001	<.001	3	2
UCEC	WHAMM →	+0.578	+1.862	<.001	<.001	3	2
UCEC	SASS6 →	+0.386	+1.823	.005	.002	3	2
UCEC	SAP30BP →	+0.225	+2.523	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,428 associations by consensus.

ANKRD33B-AS1 by DNAI3 expression — READ

Explore this box plot interactively →