DNAI3

Across TCGA patient cohorts, DNAI3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAI3-associated genes across cancer lineages are INPP4B, STAT3_pY705, and TFRC. Each is linked with DNAI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAI3-to-partner and partner-to-DNAI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by DNAI3-low versus DNAI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI3→partner) and Y-score (partner→DNAI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.258	-2.584	.007	<.001	3	2
UCEC	STAT3_pY705 →	-0.382	-1.990	<.001	<.001	3	2
UCEC	TFRC →	+0.536	+1.378	<.001	.008	3	2
UCEC	ASNS →	+0.342	+1.440	.001	.022	3	2
UCEC	Chk2_pT68 →	-0.144	-2.880	.009	.001	3	2
UCEC	4E-BP1 →	+0.228	+2.222	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

INPP4B by DNAI3 expression — UCEC

Explore this box plot interactively →