DNAI3

Across TCGA cell cohorts, DNAI3 mutation is significantly associated with the RNA expression of many other genes, with 245 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAI3-associated genes across cancer lineages are MAGEL2, MAGEB3, and DYTN. Each is linked with DNAI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAI3-to-partner and partner-to-DNAI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEL2 grouped by DNAI3-low versus DNAI3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI3→partner) and Y-score (partner→DNAI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MAGEL2 →	+0.017	+4.058	<.001	.009	3	2
LUNG_NSCLC_LUSC	MAGEB3 →	+0.039	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	DYTN →	+0.007	+4.108	<.001	.005	3	1
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
SKIN	TNP2 →	+0.026	+5.415	<.001	.004	3	1
SKIN	C16orf82 →	+0.016	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

MAGEL2 by DNAI3 expression — BLOOD_Lymphoma

Explore this box plot interactively →