DNAI2

Across TCGA patient cohorts, DNAI2 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAI2-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and PDCD4. Each is linked with DNAI2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DNAI2-to-partner and partner-to-DNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DNAI2-low versus DNAI2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI2→partner) and Y-score (partner→DNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.392	+3.459	<.001	.005	2	5
COAD	FoxM1 →	+0.342	+1.882	.022	.031	3	3
UCEC	PDCD4 →	-0.508	-1.727	<.001	.006	3	3
COAD	Shc_pY317 →	-0.160	-3.153	.022	.018	3	3
UCEC	FASN →	+0.253	+1.523	.044	.008	3	3
UCEC	C-Raf →	+0.149	+1.523	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by DNAI2 expression — COAD

Explore this box plot interactively →