DNAH8

Across TCGA pan-cancer cohorts, DNAH8 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated DNAH8 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DNAH8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAH8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, THYM, and LUAD are the cancer types where DNAH8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.884	0.294	.003	32	view →
THYM	OS	Median	All	0.604	0.975	<.001	30	view →
LUAD	DFS	Median	IV	0.194	0.734	<.001	23	view →
SKCM	OS	Median	All	0.856	0.746	<.001	20	view →
CHOL	OS	Median	All	0.133	0.743	<.001	18	view →
LIHC	OS	Median	All	0.553	0.789	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
BLCA	OS	Median	II,III,IV	0.691	0.402	.022	10	view →
CESC	OS	Median	IV	0.095	0.592	.004	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
UCS	DFS	Median	All	1.000	0.224	.047	2	view →
SARC	DFS	Median	All	0.423	0.621	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

DNAH8–UCEC (DFS)

Open the UCEC breakdown →