DNAH8

Across TCGA patient cohorts, DNAH8 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH8-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and ASNS. Each is linked with DNAH8 in more than 5 cancer types. Because this analysis shows association rather than direction, both DNAH8-to-partner and partner-to-DNAH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DNAH8-low versus DNAH8-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH8→partner) and Y-score (partner→DNAH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.737	+3.169	.002	.017	3	6
LUAD	Cyclin-B1 →	+0.571	+2.906	<.001	.001	3	6
LUAD	ASNS →	+0.357	+2.070	.020	.001	3	5
LUSC	Rb_pS807_S811 →	+0.261	+1.424	.016	.001	3	4
UCEC	Caspase-8 →	-0.229	-1.497	<.001	<.001	3	4
STAD	PAI-1 →	+0.410	+1.874	.028	.048	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Caspase-7-cleavedD198 by DNAH8 expression — STAD

Explore this box plot interactively →