DNAH7

Across TCGA pan-cancer cohorts, DNAH7 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DNAH7 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DNAH7 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAH7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, ACC, and ESCA are the cancer types where DNAH7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.912	0.487	.001	34	view →
ACC	OS	Median	All	0.245	0.832	<.001	22	view →
ESCA	OS	Median	All	0.258	0.579	.001	18	view →
STAD	DFS	Median	II,III,IV	0.844	0.623	.016	13	view →
LUSC	DFS	Median	II,III,IV	0.524	0.735	.016	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	OS	Median	IV	0.137	0.556	.025	6	view →
LIHC	OS	Median	All	0.586	0.791	.038	5	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
COAD	DFS	Median	All	0.235	0.600	.013	2	view →
LGG	OS	Median	All	0.724	0.897	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DNAH7–UCEC (DFS)

Open the UCEC breakdown →