DNAH7

Across TCGA patient cohorts, DNAH7 mutation is significantly associated with the total protein of many other genes, with 127 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH7-associated genes across cancer lineages are Caspase-7-cleavedD198, Bcl-2, and PCNA. Each is linked with DNAH7 in more than 5 cancer types. Because this analysis shows association rather than direction, both DNAH7-to-partner and partner-to-DNAH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DNAH7-low versus DNAH7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH7→partner) and Y-score (partner→DNAH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.768	+1.824	.001	.013	3	6
BRCA	Bcl-2 →	-0.570	-2.579	.006	.011	3	5
STAD	PCNA →	+0.272	+1.765	.005	.012	3	4
COAD	ASNS →	+0.417	+1.745	<.001	.004	3	4
UCEC	4E-BP1 →	+0.236	+1.231	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.478	+1.231	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

Caspase-7-cleavedD198 by DNAH7 expression — COAD

Explore this box plot interactively →