DNAH7

Across TCGA cell cohorts, DNAH7 mutation is significantly associated with the RNA expression of many other genes, with 3,135 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAH7-associated genes across cancer lineages are CHKB, WDR59, and COPS4. Each is linked with DNAH7 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAH7-to-partner and partner-to-DNAH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHKB grouped by DNAH7-low versus DNAH7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH7→partner) and Y-score (partner→DNAH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHKB →	+0.618	+1.695	<.001	<.001	3	4
LARGE_INTESTINE	WDR59 →	+0.615	+3.459	<.001	<.001	3	4
LARGE_INTESTINE	COPS4 →	+0.584	+2.415	<.001	<.001	3	4
LARGE_INTESTINE	UVSSA →	+0.751	+1.695	<.001	<.001	3	4
SOFT_TISSUE	GPT2 →	+0.895	+3.366	<.001	.002	3	3
SOFT_TISSUE	CT45A8 →	+0.612	+2.722	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,135 associations by consensus.

CHKB by DNAH7 expression — LARGE_INTESTINE

Explore this box plot interactively →