DNAH6

Across TCGA pan-cancer cohorts, DNAH6 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated DNAH6 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DNAH6 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAH6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUAD, and ACC are the cancer types where DNAH6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.920	0.294	.001	34	view →
LUAD	OS	Median	All	0.173	0.835	<.001	30	view →
ACC	DFS	Median	All	0.195	0.748	.003	15	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
READ	DFS	Median	III,IV	0.174	0.747	.005	8	view →
TGCT	DFS	Median	All	0.146	0.801	.020	6	view →
PAAD	DFS	Median	All	0.006	0.505	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BRCA	OS	Median	All	0.906	0.963	.014	4	view →
SARC	DFS	Median	All	0.168	0.598	.005	3	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	III,IV	0.772	0.463	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

DNAH6–UCEC (DFS)

Open the UCEC breakdown →