DNAH6

Across TCGA cell cohorts, DNAH6 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAH6-associated genes across cancer lineages are CARD6, ZSWIM7, and H2BC9. Each is linked with DNAH6 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAH6-to-partner and partner-to-DNAH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARD6 grouped by DNAH6-low versus DNAH6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH6→partner) and Y-score (partner→DNAH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CARD6 →	-0.662	-3.239	.001	.002	3	3
LARGE_INTESTINE	ZSWIM7 →	+0.512	+3.169	.007	.006	3	3
SKIN	H2BC9 →	-0.522	-2.000	.004	.004	3	3
SOFT_TISSUE	KLK3 →	+0.199	+2.321	<.001	.007	3	2
LUNG_NSCLC_LUSC	GRAPL →	+0.213	+3.222	.005	.004	3	2
BONE	OR51J1 →	+0.028	+3.544	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

CARD6 by DNAH6 expression — LARGE_INTESTINE

Explore this box plot interactively →