DNAH5

Across TCGA pan-cancer cohorts, DNAH5 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated DNAH5 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DNAH5 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAH5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, DLBC, and PAAD are the cancer types where DNAH5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.920	0.484	<.001	34	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
PAAD	OS	Median	All	0.140	0.590	<.001	24	view →
STAD	OS	Median	II,III,IV	0.680	0.395	.026	18	view →
ACC	DFS	Median	All	0.142	0.606	.003	15	view →
LIHC	OS	Median	All	0.249	0.519	.012	8	view →
HNSC	OS	Median	All	0.530	0.702	.008	7	view →
PRAD	DFS	Median	All	0.471	0.888	<.001	6	view →
SARC	DFS	Median	All	0.150	0.598	.003	4	view →
BLCA	OS	Median	II,III,IV	0.764	0.591	.039	4	view →
SKCM	OS	Median	IV	0.133	0.621	.019	3	view →
LUAD	OS	Median	III,IV	0.990	0.458	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

DNAH5–UCEC (DFS)

Open the UCEC breakdown →