DNAH5

Across TCGA patient cohorts, DNAH5 mutation is significantly associated with the RNA expression of many other genes, with 12,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH5-associated genes across cancer lineages are NEK2, AUNIP, and PBK. Each is linked with DNAH5 in more than 7 cancer types. Because this analysis shows association rather than direction, both DNAH5-to-partner and partner-to-DNAH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEK2 grouped by DNAH5-low versus DNAH5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH5→partner) and Y-score (partner→DNAH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NEK2 →	+0.691	+2.874	<.001	<.001	3	8
LUAD	AUNIP →	+0.545	+1.681	<.001	<.001	3	8
READ	PBK →	+0.845	+2.240	.001	.004	3	8
STAD	CPOX →	+0.416	+3.082	<.001	<.001	3	7
HNSC	ENO2 →	+0.662	+1.661	.001	.001	3	7
READ	MTPAP →	+0.513	+2.962	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,574 associations by consensus.

NEK2 by DNAH5 expression — LUAD

Explore this box plot interactively →