Across TCGA cell cohorts, DNAH2 mutation is significantly associated with the RNA expression of many other genes, with 720 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAH2-associated genes across cancer lineages are MSH4, HAUS1, and ETS2. Each is linked with DNAH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAH2-to-partner and partner-to-DNAH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH2→partner) and Y-score (partner→DNAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MSH4 →	+0.298	+3.570	<.001	.001	3	3
STOMACH	HAUS1 →	+0.971	+3.240	<.001	.003	3	3
STOMACH	ETS2 →	-1.587	-3.099	<.001	.008	3	3
LARGE_INTESTINE	LYG1 →	+0.763	+2.321	<.001	<.001	3	3
LARGE_INTESTINE	ZNF714 →	+0.769	+2.584	.003	.001	3	3
LARGE_INTESTINE	RPL22L1 →	+1.095	+1.584	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 720 associations by consensus.

Exploration

DNAH2 survival (RNA) · tumor vs normal (RNA) · all DNAH2 data types