DNAAF6

Across TCGA patient cohorts, DNAAF6 mutation is significantly associated with the RNA expression of many other genes, with 1,014 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAAF6-associated genes across cancer lineages are DBI, MRPL17, and POLR3K. Each is linked with DNAAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF6-to-partner and partner-to-DNAAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBI grouped by DNAAF6-low versus DNAAF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF6→partner) and Y-score (partner→DNAAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DBI →	+0.438	+3.346	.008	.005	3	2
UCEC	MRPL17 →	+0.393	+3.480	.001	.002	3	2
UCEC	POLR3K →	+0.465	+3.343	.004	.005	3	2
UCEC	PATL1 →	+0.466	+3.332	.008	.005	3	2
UCEC	TRAPPC2L →	+0.437	+3.162	.001	<.001	3	2
UCEC	CHAF1A →	+0.646	+2.436	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,014 associations by consensus.

DBI by DNAAF6 expression — UCEC

Explore this box plot interactively →