DNAAF6

Across TCGA patient cohorts, DNAAF6 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAAF6-associated genes across cancer lineages are EGFR_pY1068, ACC_pS79, and Annexin-1. Each is linked with DNAAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF6-to-partner and partner-to-DNAAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DNAAF6-low versus DNAAF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF6→partner) and Y-score (partner→DNAAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.312	-2.459	.005	.019	3	1
UCEC	ACC_pS79 →	+0.350	+2.000	.025	.032	3	1
UCEC	Annexin-1 →	+0.849	+3.341	<.001	.005	3	1
UCEC	TFRC →	+0.506	+3.169	.034	.019	3	1
UCEC	ATM →	-0.621	-3.321	.002	.010	3	1
UCEC	Caspase-8 →	-0.280	-3.143	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by DNAAF6 expression — UCEC

Explore this box plot interactively →