DNAAF5

Across TCGA pan-cancer cohorts, DNAAF5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DNAAF5 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DNAAF5 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated DNAAF5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, SARC, and SKCM are the cancer types where DNAAF5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.652	.018	14	view →
SARC	OS	Median	All	0.127	0.860	<.001	9	view →
SKCM	DFS	Median	All	0.087	0.757	<.001	9	view →
STAD	OS	Median	III,IV	0.113	0.642	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
GBM	DFS	Median	All	1.000	0.248	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DNAAF5–UCEC (OS)

Open the UCEC breakdown →