DNAAF5

Across TCGA pan-cancer cohorts, DNAAF5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNAAF5 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DNAAF5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DNAAF5 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

PDAC, OV, and UCEC are the cancer types where DNAAF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.251	0.437	.002	40	view →
OV	DFS	Median	All	0.935	0.643	.028	4	view →
UCEC	DFS	Tertile	III,IV	1.000	0.486	.049	4	view →
LUAD	DFS	Median	All	0.657	0.950	.006	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNAAF5–PDAC (OS)

Open the PDAC breakdown →