DNAAF5

Across TCGA patient cohorts, DNAAF5 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAAF5-associated genes across cancer lineages are NDRG1_pT346, Notch1, and Fibronectin. Each is linked with DNAAF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAAF5-to-partner and partner-to-DNAAF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDRG1_pT346 grouped by DNAAF5-low versus DNAAF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF5→partner) and Y-score (partner→DNAAF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDRG1_pT346 →	-0.379	-2.321	.049	.033	3	3
UCEC	Notch1 →	+0.165	+2.000	.002	.010	3	2
UCEC	Fibronectin →	-0.320	-2.000	.013	.010	3	1
UCEC	FoxM1 →	+0.256	+2.000	.011	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.142	-1.571	.031	.036	3	1
UCEC	JNK2 →	+0.219	+1.584	.005	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

NDRG1_pT346 by DNAAF5 expression — UCEC

Explore this box plot interactively →