DNAAF2

Across TCGA cell cohorts, DNAAF2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. CNS shows the largest number of these associations.

The most reproducible DNAAF2-associated genes across cancer lineages are PNMA6F, IFNG, and PTH2. Each is linked with DNAAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF2-to-partner and partner-to-DNAAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNMA6F grouped by DNAAF2-low versus DNAAF2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF2→partner) and Y-score (partner→DNAAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PNMA6F →	+0.012	+4.981	<.001	.008	3	2
CNS	IFNG →	+0.043	+5.321	.003	.005	3	1
CNS	PTH2 →	+0.120	+5.321	<.001	.005	3	1
CNS	ASB10 →	+0.062	+4.981	<.001	.008	3	1
CNS	UCMA →	+0.276	+5.754	<.001	.002	3	1
CNS	OR4D6 →	+0.142	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PNMA6F by DNAAF2 expression — CNS

Explore this box plot interactively →