DNAAF1

Across TCGA patient cohorts, DNAAF1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAAF1-associated genes across cancer lineages are FoxM1, Acetyl-a-Tubulin-Lys40, and MSH2. Each is linked with DNAAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF1-to-partner and partner-to-DNAAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DNAAF1-low versus DNAAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF1→partner) and Y-score (partner→DNAAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.185	+1.440	.039	.024	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.372	+1.440	.035	.024	3	2
UCEC	MSH2 →	-0.253	-2.880	.001	.001	3	2
UCEC	MSH6 →	-0.396	-1.896	<.001	.015	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.512	-3.169	.003	.018	3	2
UCEC	p62 Lck ligand →	+0.344	+2.459	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FoxM1 by DNAAF1 expression — UCEC

Explore this box plot interactively →