DNAAF1

Across TCGA cell cohorts, DNAAF1 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DNAAF1-associated genes across cancer lineages are IL36A, SLC38A8, and OR56A5. Each is linked with DNAAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF1-to-partner and partner-to-DNAAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by DNAAF1-low versus DNAAF1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF1→partner) and Y-score (partner→DNAAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL36A →	+0.026	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	SLC38A8 →	+0.056	+4.606	.002	.001	3	1
BLOOD_Lymphoma	OR56A5 →	+0.050	+3.927	.007	.004	3	1
BLOOD_Lymphoma	KRTAP10-3 →	+0.021	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	ANKRD34C →	+0.099	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	PRSS56 →	+0.151	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

IL36A by DNAAF1 expression — LUNG_SCLC

Explore this box plot interactively →