DNA2

Across TCGA patient cohorts, DNA2 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,818 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DNA2-associated proteins across cancer lineages are RFC2, CDC20_T70, and CDK1. Each is linked with DNA2 in more than 9 cancer types. Because this analysis shows association rather than direction, both DNA2-to-partner and partner-to-DNA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNA2 versus RFC2 in LSCC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNA2→partner) and Y-score (partner→DNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.423	+0.756	<.001	<.001	3	10
LUAD	CDC20_T70 →	+1.405	+0.912	<.001	<.001	3	10
LUAD	CDK1 →	+1.012	+0.821	<.001	<.001	3	10
OV	VRK3_S136 →	+0.859	+0.734	<.001	<.001	3	9
LUAD	RFC1_S368 →	+0.954	+0.810	<.001	<.001	3	9
LUAD	RFC1_T506 →	+1.099	+0.814	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,818 associations by consensus.

DNA2 vs RFC2 — LSCC

Explore this scatter interactively →