DNA2

Across TCGA cell cohorts, DNA2 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNA2-associated genes across cancer lineages are LRRC10, RAB3A, and TMEM33. Each is linked with DNA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNA2-to-partner and partner-to-DNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC10 grouped by DNA2-low versus DNA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNA2→partner) and Y-score (partner→DNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC10 →	+0.205	+4.129	<.001	.009	3	2
LARGE_INTESTINE	RAB3A →	+0.778	+3.588	.005	<.001	3	1
LARGE_INTESTINE	TMEM33 →	+0.621	+2.451	<.001	.009	3	1
LARGE_INTESTINE	TBCCD1 →	+0.529	+3.502	.006	.001	3	1
LARGE_INTESTINE	PLEKHA3 →	+0.663	+3.675	.003	<.001	3	1
LARGE_INTESTINE	TMEM9 →	+0.669	+3.502	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

LRRC10 by DNA2 expression — BLOOD_Leukemia

Explore this box plot interactively →