DMXL2

Across TCGA patient cohorts, DMXL2 mutation is significantly associated with the RNA expression of many other genes, with 6,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMXL2-associated genes across cancer lineages are ATP1B2, ACBD5, and PRPSAP2. Each is linked with DMXL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DMXL2-to-partner and partner-to-DMXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP1B2 grouped by DMXL2-low versus DMXL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMXL2→partner) and Y-score (partner→DMXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP1B2 →	-0.537	-2.744	<.001	<.001	3	6
STAD	ACBD5 →	+0.624	+2.824	.001	.001	3	4
STAD	PRPSAP2 →	+0.367	+2.840	.004	.001	3	4
STAD	RGS5 →	-1.122	-2.807	<.001	.003	3	4
UCEC	CHAF1B →	+0.558	+1.554	<.001	<.001	3	4
UCEC	LETM1 →	+0.465	+2.130	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,704 associations by consensus.

ATP1B2 by DMXL2 expression — UCEC

Explore this box plot interactively →