DMXL2

Across TCGA patient cohorts, DMXL2 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMXL2-associated genes across cancer lineages are Cyclin-B1, mTOR_pS2448, and Cyclin-E2. Each is linked with DMXL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DMXL2-to-partner and partner-to-DMXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DMXL2-low versus DMXL2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMXL2→partner) and Y-score (partner→DMXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.501	+2.906	.007	.001	3	4
UCEC	mTOR_pS2448 →	-0.100	-1.794	.008	.003	3	4
UCEC	Cyclin-E2 →	+0.099	+0.874	.021	.036	3	4
BRCA	eIF4E →	+0.165	+3.010	.026	.020	3	3
COAD	A-Raf_pS299 →	-0.136	-1.874	.020	.049	3	3
UCEC	TFRC →	+0.468	+1.263	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Cyclin-B1 by DMXL2 expression — COAD

Explore this box plot interactively →