Across TCGA pan-cancer cohorts, DMWD Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DMWD data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher DMWD Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DMWD expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

BRCA, SARC, and UCEC are the cancer types where DMWD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.660	0.924	.001	20	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	III,IV	1.000	0.430	.037	3	view →
STAD	DFS	Median	All	0.211	0.709	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: DMWD tumor-vs-normal RNA expression · all DMWD data types