Across TCGA patient cohorts, DMWD mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMWD-associated genes across cancer lineages are MSH2, p27, and Fibronectin. Each is linked with DMWD in more than 1 cancer types. Because this analysis shows association rather than direction, both DMWD-to-partner and partner-to-DMWD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMWD→partner) and Y-score (partner→DMWD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.211	-2.973	.036	.035	3	2
UCEC	p27 →	+0.190	+2.459	.047	.019	3	2
UCEC	Fibronectin →	-0.377	-2.575	.008	.010	3	1
UCEC	N-Cadherin →	-0.187	-2.115	.043	.019	3	1
UCEC	NF2 →	+0.187	+2.999	.048	.035	3	1
UCEC	PDK1_pS241 →	+0.163	+1.598	.029	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

DMWD survival (RNA) · tumor vs normal (RNA) · all DMWD data types