Across TCGA cell cohorts, DMWD mutation is significantly associated with the RNA expression of many other genes, with 178 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMWD-associated genes across cancer lineages are CCDC83, CLEC1B, and OR52E8. Each is linked with DMWD in more than 1 cancer types. Because this analysis shows association rather than direction, both DMWD-to-partner and partner-to-DMWD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMWD→partner) and Y-score (partner→DMWD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCDC83 →	+0.030	+6.022	<.001	.001	3	1
LUNG_SCLC	CLEC1B →	+0.045	+5.029	<.001	.006	3	1
LUNG_SCLC	OR52E8 →	+0.053	+5.643	<.001	.002	3	1
BLOOD_Leukemia	GUCA1C →	+0.019	+4.384	<.001	.006	3	1
LARGE_INTESTINE	SAMM50 →	+0.517	+3.212	.005	.006	3	1
LARGE_INTESTINE	RSPH4A →	+0.221	+3.259	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 178 associations by consensus.

Exploration

DMWD survival (RNA) · tumor vs normal (RNA) · all DMWD data types