DMTN

Across TCGA patient cohorts, DMTN mutation is significantly associated with the RNA expression of many other genes, with 4,994 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMTN-associated genes across cancer lineages are RNVU1-28, RNA5SP419, and RNA5SP413. Each is linked with DMTN in more than 2 cancer types. Because this analysis shows association rather than direction, both DMTN-to-partner and partner-to-DMTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-28 grouped by DMTN-low versus DMTN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMTN→partner) and Y-score (partner→DMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNVU1-28 →	+0.354	+4.705	.001	.003	3	3
UCEC	RNA5SP419 →	+0.465	+1.924	<.001	.001	3	3
UCEC	RNA5SP413 →	+0.744	+1.566	<.001	.004	3	3
UCEC	RNU6-218P →	+0.311	+1.442	.006	.007	3	3
SKCM	LINC02522 →	+0.313	+2.851	.002	.003	3	3
CESC	MAGEB6 →	+0.268	+4.320	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,994 associations by consensus.

RNVU1-28 by DMTN expression — CESC

Explore this box plot interactively →