DMTN

Across TCGA cell cohorts, DMTN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,187 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DMTN-associated GO terms across cancer lineages are Negative regulation of peptidyl-threonine phosphorylation, ATP metabolic process, and Proton motive force-driven mitochondrial ATP synthesis. Each is linked with DMTN in more than 11 cancer types. Because this analysis shows association rather than direction, both DMTN-to-partner and partner-to-DMTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of peptidyl-threonine phosphorylation grouped by DMTN-low versus DMTN-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DMTN→partner) and Y-score (partner→DMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of peptidyl-threonine phosphorylation →	+0.218	+2.502	<.001	<.001	3	12
OVARY	ATP metabolic process →	+0.079	+1.956	.004	<.001	2	11
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven mitochondrial ATP synthesis →	+0.100	+1.424	<.001	.001	2	10
UPPER_AERODIGESTIVE_TRACT	Mitochondrial electron transport, NADH to ubiquinone →	+0.081	+1.719	<.001	<.001	2	10
BLOOD_Myeloma	Aerobic respiration →	+0.069	+1.125	<.001	.009	2	10
SOFT_TISSUE	Purine nucleoside triphosphate metabolic process →	+0.052	+0.943	.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,187 associations by consensus.

Negative regulation of peptidyl-threonine phosphorylation by DMTN expression — STOMACH

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