DMRTC2

Across TCGA patient cohorts, DMRTC2 mutation is significantly associated with the RNA expression of many other genes, with 1,539 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRTC2-associated genes across cancer lineages are RNA5SP73, DHX37, and ANKRD9. Each is linked with DMRTC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTC2-to-partner and partner-to-DMRTC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by DMRTC2-low versus DMRTC2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTC2→partner) and Y-score (partner→DMRTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP73 →	+0.443	+6.837	<.001	<.001	3	2
UCEC	DHX37 →	+0.529	+2.386	<.001	.003	3	2
SKCM	ANKRD9 →	+0.785	+2.635	<.001	.005	3	2
UCEC	TRAPPC2L →	+0.387	+4.162	.007	<.001	3	2
UCEC	DAPK3 →	+0.458	+3.032	.004	<.001	3	2
UCEC	UBXN6 →	+0.373	+3.369	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,539 associations by consensus.

RNA5SP73 by DMRTC2 expression — CESC

Explore this box plot interactively →