DMRTC2

Across TCGA cell cohorts, DMRTC2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DMRTC2-associated genes across cancer lineages are HHLA1, GUCA1C, and SLC6A1. Each is linked with DMRTC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTC2-to-partner and partner-to-DMRTC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by DMRTC2-low versus DMRTC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTC2→partner) and Y-score (partner→DMRTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.011	+4.966	<.001	<.001	3	1
BLOOD_Leukemia	GUCA1C →	+0.019	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SLC6A1 →	+0.052	+3.874	<.001	.005	3	1
BLOOD_Leukemia	TACR3 →	+0.038	+4.060	<.001	.003	3	1
BLOOD_Leukemia	KRTAP4-4 →	+0.016	+4.984	<.001	.002	3	1
BLOOD_Leukemia	OVCH2 →	+1.119	+3.757	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

HHLA1 by DMRTC2 expression — BLOOD_Leukemia

Explore this box plot interactively →