DMRTA2

Across TCGA pan-cancer cohorts, DMRTA2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DMRTA2 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DMRTA2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DMRTA2 expression acts as an unfavorable survival marker.

HNSC, SCLC, and UCEC are the cancer types where DMRTA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
SCLC	OS	Median	II,III,IV	0.214	0.587	.010	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LIHC	DFS	Median	All	0.149	0.529	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DMRTA2–HNSC (DFS)

Open the HNSC breakdown →