DMRTA2

Across TCGA patient cohorts, DMRTA2 mutation is significantly associated with the RNA expression of many other genes, with 135 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRTA2-associated genes across cancer lineages are NDUFA12P1, MTCYBP15, and SNORA36C. Each is linked with DMRTA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTA2-to-partner and partner-to-DMRTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA12P1 grouped by DMRTA2-low versus DMRTA2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTA2→partner) and Y-score (partner→DMRTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	NDUFA12P1 →	+0.127	+5.878	<.001	.002	3	2
LIHC	MTCYBP15 →	+0.037	+5.544	<.001	.004	3	2
LUAD	SNORA36C →	+0.325	+4.888	.004	.005	3	2
LUAD	RN7SL826P →	+0.141	+4.554	.008	.009	3	2
LUAD	RN7SL598P →	+0.618	+6.066	<.001	<.001	3	2
LUAD	MIR4266 →	+0.562	+5.315	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 135 associations by consensus.

NDUFA12P1 by DMRTA2 expression — LIHC

Explore this box plot interactively →