DMRTA2

Across TCGA cell cohorts, DMRTA2 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMRTA2-associated genes across cancer lineages are CT45A6, IFNA10, and OR4D2. Each is linked with DMRTA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTA2-to-partner and partner-to-DMRTA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A6 grouped by DMRTA2-low versus DMRTA2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTA2→partner) and Y-score (partner→DMRTA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CT45A6 →	+0.040	+5.196	.003	.005	3	1
CNS	IFNA10 →	+0.141	+4.285	<.001	.001	3	1
CNS	OR4D2 →	+0.012	+4.772	<.001	.002	3	1
LUNG_NSCLC_LUAD	GJA10 →	+0.049	+4.212	.001	.007	3	1
LUNG_NSCLC_LUAD	SSX7 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLEC6A →	+0.039	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

CT45A6 by DMRTA2 expression — OVARY

Explore this box plot interactively →