DMRTA1

Across TCGA patient cohorts, DMRTA1 mutation is significantly associated with the RNA expression of many other genes, with 1,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRTA1-associated genes across cancer lineages are PRELID1P2, OR4F28P, and MIR6515. Each is linked with DMRTA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTA1-to-partner and partner-to-DMRTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRELID1P2 grouped by DMRTA1-low versus DMRTA1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTA1→partner) and Y-score (partner→DMRTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRELID1P2 →	+0.116	+5.339	<.001	.003	3	2
SKCM	OR4F28P →	+0.040	+4.639	<.001	<.001	3	2
UCEC	MIR6515 →	+0.246	+3.220	<.001	.005	3	2
BLCA	RNU6-929P →	+0.428	+5.444	<.001	.002	3	2
UCEC	SYAP1 →	+0.461	+3.917	.007	<.001	3	2
UCEC	TIMM22 →	+0.463	+3.691	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,034 associations by consensus.

PRELID1P2 by DMRTA1 expression — HNSC

Explore this box plot interactively →