DMRTA1

Across TCGA cell cohorts, DMRTA1 mutation is significantly associated with the RNA expression of many other genes, with 189 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMRTA1-associated genes across cancer lineages are TCERG1L, L3MBTL2, and PRSS54. Each is linked with DMRTA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRTA1-to-partner and partner-to-DMRTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCERG1L grouped by DMRTA1-low versus DMRTA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTA1→partner) and Y-score (partner→DMRTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TCERG1L →	+0.072	+3.385	<.001	.004	3	2
LARGE_INTESTINE	L3MBTL2 →	+0.561	+3.212	.007	.006	3	1
LARGE_INTESTINE	PRSS54 →	+0.023	+2.760	.001	.003	3	1
LARGE_INTESTINE	TXNDC15 →	+0.632	+3.212	.003	.006	3	1
LARGE_INTESTINE	WRAP73 →	+0.591	+3.212	.002	.006	3	1
LARGE_INTESTINE	MND1 →	+0.817	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 189 associations by consensus.

TCERG1L by DMRTA1 expression — LARGE_INTESTINE

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