DMRT3

Across TCGA pan-cancer cohorts, DMRT3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DMRT3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DMRT3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DMRT3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, LIHC, and BLCA are the cancer types where DMRT3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.170	0.811	.001	24	view →
LIHC	OS	Median	All	0.025	0.777	<.001	12	view →
BLCA	OS	Median	IV	0.153	0.599	.018	9	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →
UCEC	DFS	Median	All	0.955	0.629	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DMRT3–KIRC (OS)

Open the KIRC breakdown →