DMRT3

Across TCGA patient cohorts, DMRT3 mutation is significantly associated with the RNA expression of many other genes, with 1,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRT3-associated genes across cancer lineages are TOMM40, ZMYND19, and ELP5. Each is linked with DMRT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DMRT3-to-partner and partner-to-DMRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOMM40 grouped by DMRT3-low versus DMRT3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT3→partner) and Y-score (partner→DMRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TOMM40 →	+0.381	+2.534	.004	.001	3	3
UCEC	ZMYND19 →	+0.479	+2.906	<.001	.001	3	3
UCEC	ELP5 →	+0.345	+1.958	.005	.003	3	3
BRCA	SOCS5P5 →	+0.334	+4.995	<.001	.009	3	2
BRCA	RBMY2JP →	+0.033	+7.471	<.001	.008	3	2
UCEC	NUTF2 →	+0.432	+2.354	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,450 associations by consensus.

TOMM40 by DMRT3 expression — SKCM

Explore this box plot interactively →