DMRT3

Across TCGA patient cohorts, DMRT3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRT3-associated genes across cancer lineages are XBP1, ERK2, and Acetyl-a-Tubulin-Lys40. Each is linked with DMRT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DMRT3-to-partner and partner-to-DMRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by DMRT3-low versus DMRT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT3→partner) and Y-score (partner→DMRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.163	-1.687	.004	.040	3	3
UCEC	ERK2 →	+0.234	+2.700	.002	.006	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.424	+1.906	.038	.016	3	2
UCEC	Myosin-IIa_pS1943 →	+0.217	+1.920	.009	.009	3	2
UCEC	Chk2_pT68 →	-0.163	-3.575	.029	.002	3	2
UCEC	eIF4E →	+0.183	+3.183	.031	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

XBP1 by DMRT3 expression — UCEC

Explore this box plot interactively →