DMRT3

Across TCGA cell cohorts, DMRT3 mutation is significantly associated with the RNA expression of many other genes, with 257 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMRT3-associated genes across cancer lineages are ANKRD45, AKAP4, and CCL18. Each is linked with DMRT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRT3-to-partner and partner-to-DMRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD45 grouped by DMRT3-low versus DMRT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT3→partner) and Y-score (partner→DMRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD45 →	+0.173	+3.263	.008	.008	3	2
BREAST	AKAP4 →	+0.013	+4.672	<.001	.002	3	2
LUNG_NSCLC_LUAD	CCL18 →	+0.018	+2.142	.001	.009	3	2
LARGE_INTESTINE	HSCB →	+0.558	+3.169	.004	.009	3	1
LARGE_INTESTINE	PHF5A →	+0.514	+3.364	.005	.002	3	1
LARGE_INTESTINE	RHOXF1 →	+0.162	+2.559	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 257 associations by consensus.

ANKRD45 by DMRT3 expression — LARGE_INTESTINE

Explore this box plot interactively →