DMRT1

Across TCGA pan-cancer cohorts, DMRT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DMRT1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DMRT1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DMRT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

BLCA, ESCA, and LIHC are the cancer types where DMRT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	III,IV	1.000	0.296	.017	10	view →
ESCA	DFS	Median	II,III,IV	0.186	0.525	.019	6	view →
LIHC	OS	Median	III,IV	0.270	0.732	.021	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DMRT1–BLCA (DFS)

Open the BLCA breakdown →