DMRT1

Across TCGA patient cohorts, DMRT1 mutation is significantly associated with the RNA expression of many other genes, with 907 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRT1-associated genes across cancer lineages are PTP4A1P3, UBE2V1P5, and LINC00457. Each is linked with DMRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRT1-to-partner and partner-to-DMRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTP4A1P3 grouped by DMRT1-low versus DMRT1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT1→partner) and Y-score (partner→DMRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PTP4A1P3 →	+0.091	+5.569	<.001	.002	3	2
CESC	UBE2V1P5 →	+0.154	+4.234	<.001	.008	3	2
BLCA	LINC00457 →	+0.080	+3.251	<.001	.007	3	2
LUAD	LINC01162 →	+0.441	+3.659	.004	.009	3	2
LUAD	MIR3925 →	+0.452	+4.303	<.001	.009	3	2
COAD	AMY1A →	+0.018	+5.516	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 907 associations by consensus.

PTP4A1P3 by DMRT1 expression — CESC

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