DMRT1

Across TCGA patient cohorts, DMRT1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMRT1-associated genes across cancer lineages are Caspase-8, EGFR, and JNK_pT183_Y185. Each is linked with DMRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMRT1-to-partner and partner-to-DMRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by DMRT1-low versus DMRT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRT1→partner) and Y-score (partner→DMRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.277	-3.432	.018	.005	3	2
UCEC	EGFR →	-0.194	-2.973	.009	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-2.571	.031	.011	3	1
UCEC	p62 Lck ligand →	+0.467	+2.999	.002	.035	3	1
UCEC	PCNA →	+0.323	+3.321	.001	.010	3	1
UCEC	RAD51 →	+0.171	+3.169	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-8 by DMRT1 expression — UCEC

Explore this box plot interactively →