DMPK

Across TCGA pan-cancer cohorts, DMPK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DMPK data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DMPK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DMPK expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, LUAD, and GBM are the cancer types where DMPK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.494	0.951	<.001	44	view →
LUAD	OS	Median	III,IV	0.607	1.000	.002	17	view →
GBM	OS	Tertile	All	0.183	0.760	.024	14	view →
HNSC	DFS	Median	All	0.853	1.000	.005	11	view →
CCRCC	DFS	Median	II,III,IV	0.140	0.887	.038	6	view →
PDAC	DFS	Median	III,IV	0.673	0.256	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DMPK–LSCC (OS)

Open the LSCC breakdown →