DMPK

Across TCGA patient cohorts, DMPK mutation is significantly associated with the RNA expression of many other genes, with 1,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMPK-associated genes across cancer lineages are RPL23AP82, RNA5SP457, and MTCO3P45. Each is linked with DMPK in more than 2 cancer types. Because this analysis shows association rather than direction, both DMPK-to-partner and partner-to-DMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by DMPK-low versus DMPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMPK→partner) and Y-score (partner→DMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.399	+2.928	<.001	<.001	3	3
LUAD	RNA5SP457 →	+0.603	+5.575	<.001	<.001	3	3
LUAD	MTCO3P45 →	+0.095	+4.888	<.001	.005	3	3
LUAD	MIR3691 →	+0.644	+4.926	<.001	.002	3	2
LUAD	RPSAP38 →	+0.689	+4.962	<.001	.002	3	2
CESC	RN7SL538P →	+0.119	+4.539	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,659 associations by consensus.

RPL23AP82 by DMPK expression — UCEC

Explore this box plot interactively →